Scientist, Biochemistry

41 - Biochemistry - Redwood CIty, CA - Full Time

Scientist Biochemistry

Codexis is a biotechnology company focused on applying our directed evolution technology to improve enzyme therapeutics for the treatment of rare genetic disorders, drug manufacturing, and food processing.  We radically re-engineer enzymes to create solutions custom-tailored to individual challenges.  

Codexis seeks a highly motivated Scientist with expertise in protein biochemistry and analytical method development to join the Biochemistry Department.  Successful candidates will be part of an interdisciplinary, dynamic and enthusiastic team responsible for integrating Codexis’ core technologies with the design, optimization and validation of protein therapeutics.

Responsibilities include:

  • Reviewing and analyzing scientific literature to identify opportunities and liabilities for protein therapeutics.
  • Devising miniaturized biochemical assays to evaluate enzyme function under models of physiological conditions (e.g., stability in serum or subcellular compartments, reactivity rate, inhibition profile, selectivity, and cellular/subcellular targeting)
  • Developing and interpreting analytical methods to quantify biomarkers and enzyme activities in complex milieu (e.g. HPLC, UV-Vis Spectrophotometry, GC, GC-MS, LC-MS, and ELISA)
  • Identifying, developing, and managing external collaborators (academic, industrial partners, and CROs) to advance project needs.
  • Oral and written communication with Codexis R&D, senior leadership, and external collaborators.
  • Training of junior staff and transfer of protocols.
  • Data analysis and utilization of a LIMS system to track samples and analyses.
  • Excellent report writing and documentation skills.
  • Participation in lab organization, housekeeping, and weekly maintenance activities.

Job Requirements:

  • Ph.D. in Chemical Biology/Biochemistry preferably with 2+ years of post-doctoral or industrial experience or exceptional M.S. candidates with 10+ years of experience.
  • Detailed knowledge of biochemistry or enzymology evidenced by publication in top journals.
  • Knowledge and skills to conduct biochemical assays, interpret data, and suggest improvements.
  • Hands-on experience with analytical development (HPLC, LC-MS).
  • Experience in sample preparation from biological matrices for both small and large molecule analysis.
  • Extensive background in enzyme production, isolation, and biochemical characterization.  Experience with eukaryotic expression hosts is highly desired.
  • Background in animal models of disease is preferred.
  • Experience managing outside vendors is preferred.  
  • Ability to adapt, learn, and provide methods, analyses, materials, services in a fast paced environment.
  • Effective communication (oral and written), documentation (record keeping, lab notebook, reports, SOPs), organization, and interpersonal skills.
  • Attention to detail, safety, and good laboratory practice.

The position comes with a competitive compensation and benefits package, including paid company holidays, paid time off, health benefits, 401k match, and much more.  For more information about our plans for the future, and to be considered for this career opportunity, please visit



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