Scientist, Biochemistry

41 - Biochemistry - Redwood City, CA - Full Time

Scientist, Biochemistry

Codexis is a biotechnology company focused on applying our directed evolution technology to improve enzyme therapeutics for the treatment of rare genetic disorders, drug manufacturing, and food processing.  We radically reengineer enzymes to create solutions custom-tailored to individual challenges.  

Codexis seeks a highly motivated Scientist with expertise in protein biochemistry and analytical method development to join the Biochemistry Department with a focus on Biotherapeutics.  Successful candidates will be part of an interdisciplinary, dynamic and enthusiastic team responsible for integrating Codexis’ core technologies with the design, optimization and validation of protein therapeutics.
Responsibilities include:

  • Devising and implementing miniaturized biochemical assays to evaluate enzyme function under relevant conditions (e.g., stability in serum or subcellular compartments, activity, inhibition profile, selectivity, and cellular/subcellular targeting)
  • Developing and interpreting analytical methods to quantify biomarkers and enzyme activities in complex environments using HPLC, UV-Vis Spectrophotometry, GC, GC-MS, LC-MS, and ELISA.
  • Implementing live cell assays amenable to high through put screening.
  •  Identifying, developing, and managing external collaborators (academic, industrial partners, and CROs) to advance project needs.
  • Reviewing and analyzing scientific literature to identify opportunities and liabilities for protein therapeutics.
  • Data analysis and utilization of a LIMS system to track samples and analyses.
  • Excellent report writing and documentation skills.
  • Oral and written communication with Codexis R&D, senior leadership, and external collaborators.
  • Training of junior staff and transfer of protocols.
  • Participation in lab organization, housekeeping, and weekly maintenance activities.

Job Requirements:

  • Ph.D. in Chemical Biology/Biochemistry preferably with 2+ years of post-doctoral or industrial experience or exceptional M.S. candidates with 5-10+ years of industrial experience.
  • Detailed knowledge of biochemistry and enzymology evidenced by publication in top journals.
  • Knowledge and skills to conduct biochemical assays, interpret data, and suggest improvements.
  • Experience in mammalian cell culture, mammalian cell transfection, and protein expression.
  • Experience in sample preparation from biological matrices for both small and large molecule analysis.
  • Extensive background in enzyme isolation and biochemical characterization.  Experience with eukaryotic expression hosts is highly desired.
  • Attention to detail, safety, and good laboratory practice.
  • Effective communication (oral and written), documentation (record keeping, lab notebook, reports, SOPs), organization, and interpersonal skills.
  • Ability to adapt, learn, and provide methods, analyses, materials, services in a fast paced environment.
  • Highly proficient in MS Word, Excel, and PowerPoint.
  • Background in animal models of disease is preferred.
  • Experience managing outside vendors is preferred.  

The position comes with a competitive compensation and benefits package, including paid company holidays, paid time off, health benefits, 401k match, and much more.  For more information about our plans for the future, and to be considered for this career opportunity, please visit


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