Research Associate, Biochemistry

41 - Biochemistry - Redwood City, CA - Full Time

Research Associate, Biochemistry

Codexis is a biotechnology company focused on applying our directed evolution technology to improve enzyme therapeutics for the treatment of rare genetic disorders, drug manufacturing, and food processing. We radically reengineer enzymes to create solutions custom-tailored to individual challenges. Codexis seeks a highly motivated Research Associate with expertise in LC/MS based approaches to protein identification and quantitation to join the Biochemistry Department. Successful candidates will be part of an interdisciplinary, dynamic and enthusiastic team responsible for integrating Codexis’ core technologies with the design, optimization and validation of protein therapeutics.

Responsibilities include:

  • Developing and optimizing methods for protein mass mapping and protein quantitation using LC/MS
  • Developing and optimizing methods for preparing samples from mammalian cell culture and other biofluids for proteomics workflows
  • Implementing miniaturized biochemical assays to evaluate enzyme function under relevant conditions
  • Developing and interpreting analytical methods to quantify enzyme activities in complex environments using HPLC, UV-Vis Spectrophotometry, GC, GC-MS, LC-MS, and ELISA.
  • Identifying, developing, and managing external collaborators (academic, industrial partners, and CROs) to advance project needs.
  • Reviewing and analyzing scientific literature
  • Data analysis and utilization of a LIMS system to track samples and analyses.
  • Excellent report writing and documentation skills.
  • Oral and written communication with Codexis R&D, senior leadership, and external collaborators.
  • Training of junior staff and transfer of protocols.
  • Participation in lab organization, housekeeping, and weekly maintenance activities.

Job Requirements:

  • A degree in Biochemistry, Biotechnology, Molecular Biology, Chemistry, or related field is necessary.
  • Applicants with BA/BS must have at least 4 or more years of industry experience. Applicants with MS degree must have 2 or more years of industry experience.
  • Applicants must have at least 2 or more years of experience in performing LC/MS based protein identification or quantitation experiments.
  • Experience in enzymology, including enzyme kinetics, protein characterization, analytical biochemistry, and HTP-assay development.
  • Knowledge of recombinant expression in bacteria.  Familiarity with additional expression systems is desirable.
  • Experience in cell culture is desirable.
  • Familiarity/ interest in learning to operate lab automation equipment. Experience with Biomek, Tecan and/or other liquid handling systems desirable.
  • High level of flexibility and ability to work under tight timelines in a team setting.
  • Experience with LIMS and knowledge of statistics.
  • Highly proficient in MS Word, Excel, and PowerPoint
  • Good written and oral communication skills.
  • Attention to detail, safety and good lab practice.

The position comes with a competitive compensation and benefits package, including paid company holidays, paid time off, health benefits, 401k match, and much more.  For more information about our plans for the future, and to be considered for this career opportunity, please visit


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