Process Development Scientist

49 - Fermentation - Redwood City, CA - Full Time

At Codexis, we are creating sustainable chemicals, pharmaceutical processes, and renewable ingredients that make industry more efficient, productive and profitable. Industrial biotechnology from Codexis reengineers enzymes and microorganisms – nature’s catalysts – and puts them to work to solve real global challenges for the world’s largest companies.


Position Description: 

Codexis is seeking a Process Development Scientist to work within the Bioprocess Development team focused on protein purification and fundamental characterization of therapeutic and diagnostic enzymes. This position will be part of a dynamic team responsible for bioprocess development scale up and tech transfer of enzyme product manufacturing.
• Development of purification processes for newly evolved enzymes expressed in microbial hosts.
• Development of unit operations at the bench -scale (10L) such as, centrifugation, homogenization, crystallization, ultra-filtration, depth filtration and chromatography.
• Production of purified enzymes for animal studies, diagnostic tests, reference standards, and preliminary stability studies.
• Perform analyses including enzyme activity, SDS-PAGE, SE-HPLC, LAL, host cell-DNA, host cell protein, as necessary.
• Characterization of the physicochemical properties of newly evolved enzymes such as pI, molecular size, pH and temperature stability to provide relevant information purification development.
• Troubleshoot and adapt analytical methods to quantify yield, activity, and purity at various stages of the manufacturing process.
• Providing troubleshooting support to pilot scale manufacturing operations.
• Working within multidisciplinary project teams to design and execute process development campaigns, interpreting data, and working with other team members to integrate results into process designs and overall project plans.
• Independently break down complex problems, propose experimental approach, and provide definitive solutions.
• Troubleshoot and maintain analytical instruments, particularly HPLC.
• Identifying and evaluating new technologies for downstream processing and analysis.
• Authoring and review of equipment and process SOPs. 

 Job Requirements:
• Education: BS, MS or Ph.D. in Biochemistry, Biological Science, or related discipline, BS with 10+ years, MS with 6+ years or Ph.D. with 3+ years industry experience purifying and analyzing enzymes.
• Sound understanding of protein biochemistry and recombinant protein expression in microbial hosts relevant to downstream purification.
• Strong technical background and direct hands-on experience with downstream processing unit operations such as preparative chromatography, centrifugation, homogenization, micro filtration, ultra-filtration, sterile filtration, etc.
• Proficient at protein purification using affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography. 
• Experienced in enzyme activity, protein characterization including primary structure, post-translational modifications, degradations, identification of process/product related impurities, and protein determination.
• Experimental design and data analysis capabilities including Design of Experiments (DOE).
• Understanding of engineering issues involved in scale up and possesses both practical and analytical skills to implement relevant scale down models.
• Ability to prioritize responsibilities, multi-task and remain flexible with changing needs.
• Must be motivated and able to work under tight deadlines.
• Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
• Able to work effectively in cross functional teams to solve manufacturing problems or implement improved procedures.
• Mentor and supervise staff as well as work effectively with management teams.
• Some travel to manufacturing sites will be required.


The position comes with a competitive compensation and benefits package. For more information about our plans for the future, and to be considered for this career opportunity, please visit



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