Codexis

Process Development Scientist

49 - Fermentation - Redwood City, CA - Full Time

At Codexis, we are creating sustainable chemicals, pharmaceutical processes, and renewable ingredients that make industry more efficient, productive and profitable. Industrial biotechnology from Codexis reengineers enzymes and microorganisms – nature’s catalysts – and puts them to work to solve real global challenges for the world’s largest companies.

 

Position Description: 

Codexis is seeking a Process Development Scientist to work within the Bioprocess Development team focused on protein purification and fundamental characterization of therapeutic and diagnostic enzymes. This position will be part of a dynamic team responsible for bioprocess development scale up and tech transfer of enzyme product manufacturing.
 
Responsibilities:
• Development of purification processes for newly evolved enzymes expressed in microbial hosts.
• Development of unit operations at the bench -scale (10L) such as, centrifugation, homogenization, crystallization, ultra-filtration, depth filtration and chromatography.
• Production of purified enzymes for animal studies, diagnostic tests, reference standards, and preliminary stability studies.
• Perform analyses including enzyme activity, SDS-PAGE, SE-HPLC, LAL, host cell-DNA, host cell protein, as necessary.
• Characterization of the physicochemical properties of newly evolved enzymes such as pI, molecular size, pH and temperature stability to provide relevant information purification development.
• Troubleshoot and adapt analytical methods to quantify yield, activity, and purity at various stages of the manufacturing process.
• Providing troubleshooting support to pilot scale manufacturing operations.
• Working within multidisciplinary project teams to design and execute process development campaigns, interpreting data, and working with other team members to integrate results into process designs and overall project plans.
• Independently break down complex problems, propose experimental approach, and provide definitive solutions.
• Troubleshoot and maintain analytical instruments, particularly HPLC.
• Identifying and evaluating new technologies for downstream processing and analysis.
• Authoring and review of equipment and process SOPs. 

 Job Requirements:
• Education: BS, MS or Ph.D. in Biochemistry, Biological Science, or related discipline, BS with 10+ years, MS with 6+ years or Ph.D. with 3+ years industry experience purifying and analyzing enzymes.
• Sound understanding of protein biochemistry and recombinant protein expression in microbial hosts relevant to downstream purification.
• Strong technical background and direct hands-on experience with downstream processing unit operations such as preparative chromatography, centrifugation, homogenization, micro filtration, ultra-filtration, sterile filtration, etc.
• Proficient at protein purification using affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography. 
• Experienced in enzyme activity, protein characterization including primary structure, post-translational modifications, degradations, identification of process/product related impurities, and protein determination.
• Experimental design and data analysis capabilities including Design of Experiments (DOE).
• Understanding of engineering issues involved in scale up and possesses both practical and analytical skills to implement relevant scale down models.
• Ability to prioritize responsibilities, multi-task and remain flexible with changing needs.
• Must be motivated and able to work under tight deadlines.
• Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
• Able to work effectively in cross functional teams to solve manufacturing problems or implement improved procedures.
• Mentor and supervise staff as well as work effectively with management teams.
• Some travel to manufacturing sites will be required.

 

The position comes with a competitive compensation and benefits package. For more information about our plans for the future, and to be considered for this career opportunity, please visit www.codexis.com.

 

EOE
PRINCIPALS ONLY
NO AGENCIES OR THIRD PARTIES

Apply: Process Development Scientist
* Required fields
First name*
Last name*
Email address*
Location
Phone number*
Resume*

Attach resume as .pdf, .doc, or .docx (limit 2MB) or paste resume

Paste your resume here or attach resume file

Cover Letter*
In 150 characters or fewer, tell us what makes you unique. Try to be creative and say something that will catch our eye!*
Do you have a BS, MS or Ph.D. in Biochemistry, Biological Science, or related discipline, BS with 10+ years, MS with 6+ years or Ph.D. with 3+ years industry experience purifying and analyzing enzymes?*
How did you hear about this position?*
If you were referred to this position by an employee of Codexis, please write in their name below.
Forward this Position
Recipient email address (one)
Your name
Your email address
Enter a message (optional)
Human Check*