Bioinformatics Scientist I

54 - Computational Biology - Redwood City, CA - Full Time

Structural Biologist: Bioinformatics Scientist I


At Codexis, we are creating sustainable chemicals, pharmaceutical processes, and renewable ingredients that make industry more efficient, productive and profitable.  Codexis reengineers enzymes – nature’s catalysts – and puts them to work to solve real global challenges for the world’s largest companies.

We are looking for an individual with a solid foundation in structural biology to join our computational biology group.  The candidate will support the directed evolution efforts in R&D by providing insight into the structure of the target engineered enzyme.  The individual will be expected to propose directed evolution strategies, analyze screening results, and effectively communicate their observations to a broader team.  The candidate will also be expected to work closely with the business development group to process and analyze customer screening results and aid in the drafting of proposals. 

Skills and Responsibilities:

  • Generate reliable structural models of enzymes.    
  • In-silico docking of substrates/products/transition states in the active site of an enzyme.
  • Carry out quantum mechanics calculations on reaction trajectories to inform the feasibility of chemical transformations.
  • A good grasp of statistics.
  • A solid understanding of enzyme mechanisms.
  • A good understanding of molecular biology.
  • Comfortable in the use of structure visualization software such as MOE, Discover Studio, Pymol etc.
  • Experienced in computation protein design software.


  • A PhD or Postdoctoral emphasis in computational or structural biology.
  • Experience writing proposals.
  • A solid publication record.
  • Excellent written and oral communication skills.
  • A team player who is comfortable collaborating with many individuals across the company.  
  • Strong organizational skills.


The position comes with a competitive compensation and benefits package. For more information about our plans for the future, and to be considered for this career opportunity, please visit

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