Codexis

Associate Director/Principal Scientist, Biotherapeutics Translational Biology

41 - Biochemistry - Redwood City, CA - Full Time

Associate Director or Principal Scientist, Biotherapeutics Translational Biology

Codexis, Inc. (Nasdaq: CDXS) is a protein engineering industry leader with successful track record of developing novel enzymes used as biocatalysts for the commercial production of small molecule pharmaceuticals, chemicals used in the food industry, as well as multiple other applications. Codexis has also applied its CodeEvolver technology platform to discover and develop novel biotherapeutics for the treatment of rare genetic disorders, among other indications with significant unmet medical need.  

In 2017, the company announced a broad collaboration with Nestle Health Science, in which Nestle took an option to co-develop and potentially commercialize Codexis’ first self-developed therapeutic candidate, CDX-6114 for the treatment of Phenylketonuria (PKU), and also gained access to employ Codexis’ protein engineering platform in a multi-project partnership for the discovery and development of new therapeutically relevant enzymes. This transaction marked the company’s first partnership for an internally developed biotherapeutic product, and validated the CodeEvolver protein engineering platform as a biotherapeutic discovery engine.

Codexis is seeking an experienced scientific leader with in vivo expertise in drug discovery and development. This is a leadership role that will lead the design, management and execution of all in vivo PK, PK/PD, immunogenicity, efficacy and non-GLP safety studies supporting the Codexis biotherapeutic portfolio. With a large network of academic partners and CROs that run many of Codexis in vivo studies, it is expected that this Translational Biology leader will interface and manage interactions with multiple stakeholders, inside and outside the company. Successful execution of Translational Biology studies will require in depth expertise in disease biology and pathophysiology, biotherapeutic PK and PK/PD relationship, as well as bioanalytical sciences that enable accurate quantification and characterization of drugs and PD biomarkers in different biological matrices. Also, in this role, the successful candidate will manage a team of talented and experienced PhD and non-PhD level scientists with specific expertise in various areas of translational biology. As such, the candidate will be required to provide scientific leadership, mentoring and management guidance to his/her team. Candidates with a proven track record of leading teams and managing highly effective PhD and non-PhD level direct reports are highly encouraged to apply. Successful candidates will be part of a growing interdisciplinary, dynamic and enthusiastic team responsible for further expanding Codexis’ biotherapeutic project portfolio and maximizing Codexis’ core technologies for the design, optimization and validation of protein therapeutics.

Responsibilities include:

  • Lead a talented group of PhD and non-PhD scientists responsible for the design, execution and data interpretation of all in vivo studies supporting the biotherapeutic research portfolio.
  • Lead multi-disciplinary project teams to discover, optimize and develop novel biotherapeutics in niche indications.
  • Play an active role in project inception and risk assessment.
  • Work effectively and in close partnership with leaders of other functional areas within and outside the biotherapeutic organization.
  • Develop sensitive and specific bioanalytical assays to accurately characterize drug PK, PK/PD and immunogenicity in multiple animal models.
  • Provide scientific leadership to the Translational Biology group and act as the point person for all non-regulated in vivo studies run by Codexis.
  • Generate data supporting development candidate nomination and work effectively with development teams to ensure smooth transitions of assets from research to development.   
  • Identify, develop, and manage external collaborators (academic, industrial partners, and CROs) to advance project needs.
  • Work closely with leaders and scientists from other Codexis functions and ensure full integration of his/her team within the overall organization.
  • Ensure clear and effective oral and written communication of plans, results and ideas with Codexis R&D, senior leadership, and external collaborators.
  • Provide hand-on training to junior staff as well as to external collaborators when needed.
  • Apply highest standards for data quality and analytical tools and use effective informatics tools for data visualization and communication.

Job Requirements:

  • Ph.D. in Pharmacology, Physiology or related fields and/or D.V.M. with a minimum of 12 years of biotech/pharma industry experience.
  • Proven track record of management of PhD level scientists in an industry setting.
  • Highly proficient in in vivo study design to assess efficacy, safety, PK, PD and immunogenicity of biotherapeutic proteins in healthy animals and disease models as evidenced by track record of publications in top tiered peer-reviewed scientific journals.
  • Demonstrated contributions to advancing lead molecules to clinical candidate nomination on multiple programs.
  • Significant experience developing, optimizing and running quantitative state-of-the art bioanalytical assays using multiple technology platforms.  
  • Key contributor to lead discovery and optimization strategies in relevant therapeutic areas.
  • Ability to troubleshoot technical and operational issue related to in vivo studies and bioanalytical assays.
  • Ability to adapt, learn, and provide methods, analyses, materials, services in a fast paced environment.
  • Effective communication (oral and written), documentation (record keeping, lab notebook, reports, SOPs), organization, and interpersonal skills.
  • Attention to detail, safety, and good laboratory practice.

The position comes with a competitive compensation and benefits package, including paid company holidays, paid time off, health benefits, 401k match, and much more.  For more information about our plans for the future, and to be considered for this career opportunity, please visit www.codexis.com.

EOE

PRINCIPALS ONLY

NO AGENCIES OR THIRD PARTIES

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